| Description: | IFN-gamma (Interferon-gamma), a type II interferon produced by immune cells, notably T-cells and NK cells, plays pivotal roles in antimicrobial, antiviral, and antitumor responses. Operating via the JAK-STAT pathway, IFN-gamma engages its receptor IFNGR1, triggering events that lead to STAT1 activation, translocation to the nucleus, and transcription of IFN-gamma-regulated genes. Crucial in class I antigen presentation, IFN-gamma enhances peptide loading onto MHC I. Additionally, it up-regulates MHC II complexes and regulates hematopoietic stem cells, showcasing its diverse and critical functions in immune responses and hematopoiesis. Animal-Free IFN-gamma Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIFN-gamma protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IFN-gamma Protein, Mouse (His) is 133 a.a., with molecular weight of ~16.5 kDa. |
