| Description: | CDK2, a vital serine/threonine-protein kinase, crucially regulates the cell cycle, especially in meiosis. It phosphorylates various substrates (CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2), orchestrating centrosome duplication and DNA synthesis initiation at G1-S transition. Activated by cyclin E and A2, CDK2 governs the S phase to mitosis transition. It maintains H3K27me3 and epigenetic gene silencing by phosphorylating EZH2, influencing DNA damage responses, G1-S phase checkpoint, BRCA2 phosphorylation, and homologous recombination-dependent repair. CDK2 participates in signaling pathways like vitamin D-mediated growth inhibition, NO-mediated signaling, and phosphorylates substrates like FOXP3 and ERCC6, showcasing its multifaceted cellular role. CDK2 Protein, Human (His) is the recombinant human-derived CDK2 protein, expressed by E. coli, with N-6*His labeled tag. The total length of CDK2 Protein, Human (His) is 298 a.a., with molecular weight of 32-35 kDa. |
