| Description: | PF-4/CXCL4 Protein, released during platelet aggregation, crucially influences physiological processes. It neutralizes heparin's anticoagulant effect with higher affinity than chondroitin-4-sulfate chains. PF-4 also exhibits chemotaxis for neutrophils and monocytes, contributing to immune responses. As an inhibitor of endothelial cell proliferation, the shorter variant is more potent. Structurally forming a homotetramer, PF-4 interacts with TNFAIP6 through its Link domain, emphasizing its role in intricate molecular interactions. These multifaceted functions underscore PF-4/CXCL4's importance in regulating hemostasis, immune responses, and vascular processes. Animal-Free PF-4/CXCL4 Protein, Human (His) is the recombinant human-derived animal-FreePF-4/CXCL4 protein, expressed by E. coli, with N-His labeled tag. The total length of Animal-Free PF-4/CXCL4 Protein, Human (His) is 70 a.a., with molecular weight of ~8.58 kDa. |
