AF12198 [CAS 185413-30-3]
Partner: MedChemexpress LLC
| CAS No: | 185413-30-3 |
| Applications: | COVID-19-immunoregulation |
| MW: | 1895.12 |
| Formula: | C96H123N19O22 |
| SMILES: | O=C(N1[C@@H](CCC1)C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N2[C@@H](CC2)C(N[C@H](C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N[C@H](C(N)=O)CC(C)C)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)CC5=CC=C(C=C5)O)=O)CC6=CNC7=CC=CC=C67)=O)=O)[C@H]([C@H](O)C)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC8=CC=CC=C8)=O)=O)CC9=CNC%10=CC=CC=C9%10)=O |
| Purity: | 99.75 |
| Description: | AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8 nM) but not the human type II receptor (IC50=6.7 �M) or the murine type I receptor (IC50>200 �M). AF12198 inhibits IL-1-induced IL-8 production (IC50=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC50=9 nM) in vitro. AF12198 has anti-inflammatory activities and�blocks responses to IL-1 in vivo[1]. |
| Shipping Conditions: | Ship on cold packs |
| Usage: | Research Use Only |
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