R18 (TFA)
Partner: MedChemexpress LLC
| Applications: | Cancer-Kinase/protease |
| MW: | 2423.73 |
| Formula: | C103H158F3N27O31S3 |
| SMILES: | OC(C(F)(F)F)=O.O=C(N1[C@@H](CCC1)C(O)=O)[C@H](CC(C)C)NC([C@H](CS)NC([C@H](CCSC)NC([C@H](CC(N)=O)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H]2N(CCC2)C([C@H](C(C)C)NC([C@H](CS)NC([C@@H](NC([C@@H]3CCCN3)=O)CC4=CN=CN4)=O)=O)=O)=O)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O)=O)=O)=O |
| Purity: | 99.72 |
| Description: | R18 TFA is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1[1]. |
| Shipping Conditions: | Ship on cold packs |
| Usage: | Research Use Only |
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