Description: | T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-?B driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC50s of 2.7 ??M, 2.9 ?M, 2.66 ?M and 2.66 ?M for IFN-?, IL-1?, IL-6 and TNF-?, respectively[1][2]. |