Data Sheet

MSDS

SB-267268 [CAS 205678-26-8]

CAS No:	205678-26-8
Applications:	Cancer-programmed cell death
MW:	451.44
Formula:	C₂₂H₂₄F₃N₃O₄
SMILES:	O=C(O)C[C@H]1C(N(CC(F)(F)F)CC2=CC(OCCCNC3=NC=CC=C3)=CC=C2C1)=O
Description:	SB-267268 is a selective and nonpeptidic alpha(v)beta3 (αvβ3) and alpha(v)beta5 (αvβ5) integrins antagonist, with Kis of 0.9, 0.5 and 0.7 nM for human αvβ3, monkey αvβ3 and human αvβ5, respectively. SB-267268 inhibits human and mouse αvβ3 with IC50s of 0.68 and 0.29 nM, respectively. SB-267268 reduces angiogenesis and VEGF expression[1].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only