Data Sheet

MSDS

(R)-CR8 (trihydrochloride) [CAS 1786438-30-9]

CAS No:	1786438-30-9
Applications:	Cancer-Kinase/protease
MW:	540.92
Formula:	C₂₄H₃₂Cl₃N₇O
SMILES:	CC[C@@H](NC1=NC(NCC2=CC=C(C3=NC=CC=C3)C=C2)=C4N=CN(C(C)C)C4=N1)CO.[H]Cl.[H]Cl.[H]Cl
Purity:	98.95
Description:	(R)-CR8 (CR8) trihydrochloride, a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 trihydrochloride inhibits CDK1/cyclin B (IC50=0.09 ?M), CDK2/cyclin A (0.072 ?M), CDK2/cyclin E (0.041 ?M), CDK5/p25 (0.11 ?M), CDK7/cyclin H (1.1 ?M), CDK9/cyclin T (0.18 ?M) and CK1?/? (0.4 ?M). (R)-CR8 trihydrochloride induces apoptosis and has neuroprotective effect[1][2]. (R)-CR8 trihydrochloride acts as a molecular glue degrader that depletes cyclin K[3].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only