Description: | (R)?-?CR8 (CR8), a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)?-?CR8 inhibits CDK1/cyclin B (IC50=0.09 ?M), CDK2/cyclin A (0.072 ?M), CDK2/cyclin E (0.041 ?M), CDK5/p25 (0.11 ?M), CDK7/cyclin H (1.1 ?M), CDK9/cyclin T (0.18 ?M) and CK1?/? (0.4 ?M). (R)?-?CR8 induces apoptosis and has neuroprotective effect[1][2]. (R)-CR8 acts as a molecular glue degrader that depletes cyclin K[3]. |