Data Sheet

MSDS

Acalabrutinib [CAS 1420477-60-6]

CAS No:	1420477-60-6
Applications:	Cancer-Kinase/protease
MW:	465.51
Formula:	C₂₆H₂₃N₇O₂
SMILES:	O=C(NC1=NC=CC=C1)C2=CC=C(C3=C4C(N)=NC=CN4C([C@H]5N(C(C#CC)=O)CCC5)=N3)C=C2
Purity:	99.88
Description:	Acalabrutinib (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL)[1][2]. Acalabrutinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only