VU 0240551 [CAS 893990-34-6]
Partner: MedChemexpress LLC
| CAS No: | 893990-34-6 |
| MW: | 342.44 |
| Formula: | C16H14N4OS2 |
| SMILES: | O=C(CSC1=NN=C(C2=CC=CC=C2)C=C1)NC3=NC(C)=CS3 |
| Purity: | 99.97 |
| Description: | VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission[1][2]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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