MRT-2359 [CAS 2803881-11-8]
Partner: MedChemexpress LLC
| CAS No: | 2803881-11-8 |
| Applications: | Cancer-programmed cell death |
| MW: | 495.38 |
| Formula: | C22H17F4N3O6 |
| SMILES: | O=C(NC1=CC(OC(F)(F)F)=CC=C1F)OCC2=CC=C3C(C(N(C4C(NC(CC4)=O)=O)C3)=O)=C2 |
| Purity: | 99.98 |
| Description: | MRT-2359 is an orally active and potent degrader of GSPT1 (IC50: >30 nM and <300 nM) with anti-tumor activity. MRT-2359 also inhibits the growth of resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells. MRT-2359 exhibits preferential activity in MYC-driven cell lines, such as N- and L-MYC high NSCLC and SCLC patient-derived xenografts (PDXs)[1][2]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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