BAY 61-3606 (dihydrochloride) [CAS 648903-57-5]
Partner: MedChemexpress LLC
| CAS No: | 648903-57-5 |
| Applications: | COVID-19-immunoregulation |
| MW: | 463.32 |
| Formula: | C20H20Cl2N6O3 |
| SMILES: | O=C(N)C1=CC=CN=C1NC2=NC(C3=CC=C(C(OC)=C3)OC)=CC4=NC=CN24.[H]Cl.[H]Cl |
| Purity: | 99.91 |
| Description: | BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM an IC50 of 10 nM[1]. BAY 61-3606 dihydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell[2]. BAY 61-3606 dihydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates[3]. Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells[4]. |
| Shipping Conditions: | Ship on cold packs |
| Usage: | Research Use Only |
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