D18 [CAS 2230218-36-5]
Partner: MedChemexpress LLC
| CAS No: | 2230218-36-5 |
| Applications: | COVID-19-immunoregulation |
| MW: | 364.49 |
| Formula: | C21H28N6 |
| SMILES: | NC(N=C1NCCCC)=NC(C1=N2)=CC=C2CC(C=C3)=CC=C3CN(C)C |
| Description: | D18 is an immune modulator. D18 acts as a TLR7/8 dual agonist (EC50=24 nM for hTLR7 and 10 nM for hTLR8, respectively). D18 increases PD-L1 expression through epigenetic regulation, thus sensitizing tumors to PD-1/PD-L1 blockade. D18 is a ADC cytotoxin uesd for the systhesis of ADC HE-S2[1]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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