NLRP3/AIM2-IN-3 [CAS 1787787-60-3]
Partner: MedChemexpress LLC
| CAS No: | 1787787-60-3 |
| Applications: | COVID-19-immunoregulation |
| MW: | 266.29 |
| Formula: | C16H14N2O2 |
| SMILES: | O=C(NC1=CC=CC(O)=C1)CC2=CC3=C(C=C2)C=CN3 |
| Purity: | 98.00 |
| Description: | NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 � 0.008 ?M. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization[1]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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