Data Sheet

MSDS

GSK-25 [CAS 874119-56-9]

CAS No:	874119-56-9
Applications:	Neuroscience-Neuromodulation
MW:	513.33
Formula:	C₂₄H₁₆Cl₂F₂N₆O
SMILES:	ClC1=CC(C2=NC(C3=C(F)C=C(Cl)C=C3)C(C(NC4=C(F)C=C(NN=C5)C5=C4)=O)=C(C)N2)=CC=N1
Purity:	99.68
Description:	GSK-25 is a potent, selective and orally bioavailable ROCK1 inhibitor (IC50=7 nM). GSK-25 maintains good selectivity against a panel of 31 kinases (>100 fold), as well as RSK1 and p70S6K (RSK1: IC50=398 nM, p70S6K: IC50=1 ?M). GSK-25 inhibits P450 profile (IC50s of 2.5, 5.2, 2.5 �M for CYP2C9, CYP2D6, CYP3A4, respectively)[1].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only