Description: | (1R,3S)-Compound E is the inactive isomer of Compound E (HY-14176), and can be used as an experimental control. Compound E is a ?-secretase inhibitor. Compound E bloks ?-amyloid(40), ?-amyloid(42), and Notch ?-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively. |