Data Sheet

MSDS

AES-350 [CAS 847249-57-4]

CAS No:	847249-57-4
Applications:	Cancer-programmed cell death
MW:	312.36
Formula:	C₁₈H₂₀N₂O₃
SMILES:	O=C(NO)C1=CC=C(NC(C2=CC=C(C(C)(C)C)C=C2)=O)C=C1
Purity:	98.02
Description:	AES-350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0.0244 ?M and 0.035 ?M, respectively. AES-350 is also against HDAC3, HDAC8 in an enzymatic activity assay with IC50 values of 0.187 ?M and 0.245 ?M, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research[1].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only