JKE-1674 [CAS 2421119-60-8]
Partner: MedChemexpress LLC
| CAS No: | 2421119-60-8 |
| Applications: | Cancer-programmed cell death |
| MW: | 451.30 |
| Formula: | C20H20Cl2N4O4 |
| SMILES: | O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)/C(C[N+]([O-])=O)=N/O |
| Purity: | 98.30 |
| Description: | JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and an active metabolite of GPX4 inhibitor ML-210. JKE-1674, an analog of ML-210 in which the nitroisoxazole ring is replaced with an ?-nitroketoxime. JKE-1674 can convert into a nitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML-210 and is completely rescued by ferroptosis inhibitors[1][2][3]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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