Data Sheet

MSDS

Fludarabine triphosphate (trisodium)

Applications:	Cancer-programmed cell death
MW:	591.12
Formula:	C₁₀H₁₂FN₅Na₃O₁₃P₃
SMILES:	O[C@@H]([C@@H]1O)[C@](O[C@@H]1CO[P](O[P](O[P](O)(O[Na])=O)(O[Na])=O)(O[Na])=O)([H])N2C3=NC(F)=NC(N)=C3N=C2
Purity:	95.0
Description:	Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 ?M and a Ki of 6.1 ?M. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis[1][2].
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only