BMS-986251 [CAS 2460133-35-9]
Partner: MedChemexpress LLC
| CAS No: | 2460133-35-9 |
| Applications: | COVID-19-immunoregulation |
| MW: | 667.61 |
| Formula: | C30H29F8NO5S |
| SMILES: | O=C([C@H]1C[C@H](C)[C@H](C(N2CC[C@@]3(S(=O)(C4=CC=C(F)C=C4)=O)C5=CC=C(C(C(F)(F)F)(F)C(F)(F)F)C=C5CC[C@@]23[H])=O)CC1)O |
| Description: | BMS-986251 is an orally active and selective ROR?t inverse agonist with an EC50 of 12 nM for ROR?t GAL4. BMS-986251 inhibits IL-17 with an EC50 of 24 nM in human whole blood assay. BMS-986251 demonstrates robust efficacy in mouse acanthosis and Imiquimod-induced (HY-B0180) models (preclinical models of psoriasis)[1]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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