Data Sheet

MSDS

(1S,2S)-Bortezomib [CAS 1132709-14-8] (10mM in DMSO)

CAS No:	1132709-14-8
Applications:	Cancer-Kinase/protease
MW:	384.24
Formula:	C₁₉H₂₅BN₄O₄
SMILES:	OB([C@H](NC([C@@H](NC(C1=NC=CN=C1)=O)CC2=CC=CC=C2)=O)CC(C)C)O
Purity:	96.59
Description:	(1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-?B. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans[1][2][3].
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only