Data Sheet

MSDS

AMG 511 [CAS 1253573-53-3]

CAS No:	1253573-53-3
Applications:	Cancer-Kinase/protease
MW:	517.58
Formula:	C₂₂H₂₈FN₉O₃S
SMILES:	NC1=NC(C2=CC([C@H](N3CCN(S(=O)(C)=O)CC3)C)=CN=C2NC4=CC(F)=C(OC)N=C4)=NC(C)=N1
Purity:	99.38
Description:	AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks, with Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3K?, ?, ? and ?, respectively. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease. AMG 511 exhibits anti-tumor activity in mouse glioblastoma xenograft model[1].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only