Data Sheet

MSDS

AZD3839 (free base) [CAS 1227163-84-9]

CAS No:	1227163-84-9
Applications:	Cancer-programmed cell death
MW:	431.41
Formula:	C₂₄H₁₆F₃N₅
SMILES:	FC1=C2C([C@](C3=CC=CC(C4=CN=CN=C4)=C3)(C5=CC(C(F)F)=NC=C5)N=C2N)=CC=C1
Purity:	99.98
Description:	AZD3839 free base is a potent and selective orally active, brain-permeable BACE1 inhibitor (Ki=26 nM). AZD3839 free base shows 14 and >1000-fold selectivity against BACE2 and cathepsin D, respectively. AZD3839 free base exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid A? levels in mouse, guinea pig, and non-human primate. AZD3839 free base can be used for the research of Alzheimer's disease[1][2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only