Data Sheet

MSDS

BS-181 [CAS 1092443-52-1]

CAS No:	1092443-52-1
Applications:	Cancer-Kinase/protease
MW:	380.53
Formula:	C₂₂H₃₂N₆
SMILES:	CC(C1=C(N=C(C=C2NCC3=CC=CC=C3)NCCCCCCN)N2N=C1)C
Purity:	98.10
Description:	BS-181 is a potent and selective CDK7 inhibitor (IC50=21 nM) than Seliciclib (HY-30237). BS-181 is also against CDK2, CDK5 and CDK9 with IC50 values of 880, 3000 and 4200 nM, respectively (fails to block CDK1, 4 and 6). BS-181 inhibits a panel of cancer cells growth (IC50=11.5 ?M-37.3 ?M) and induces cell apoptosis. BS-181 has the potential for the research of cancer therapy[1][2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only