Data Sheet

MSDS

(1E)-CFI-400437 (dihydrochloride) [CAS 1247000-76-5]

CAS No:	1247000-76-5
Applications:	Cancer-Kinase/protease
MW:	565.49
Formula:	C₂₉H₃₀Cl₂N₆O₂
SMILES:	Cl[H].Cl[H].COC1=CC(/C2=C/C3=CC4=C(C(/C=C/C5=CC=C(N=C5)N6CCN(CC6)C)=NN4)C=C3)=C(C=C1)NC2=O
Purity:	98.89
Description:	(1E)-CFI-400437 dihydrochloride is a potent PLK4 (IC50= 0.6 nM) inhibitor and selective against other members of the PLK family (>10 ?M). (1E)-CFI-400437 dihydrochloride inhibits Aurora A, Aurora B, KDR and FLT-3 with IC50s of 0.37, 0.21, 0.48, and 0.18 ?M, respectively. Antiproliferative activity[1].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only