GCN2-IN-6 [CAS 2183470-09-7]
Partner: MedChemexpress LLC
| CAS No: | 2183470-09-7 |
| Applications: | Cancer-Kinase/protease |
| MW: | 485.29 |
| Formula: | C19H12Cl2F2N4O3S |
| SMILES: | O=S(C1=CC(Cl)=CC(CO)=C1Cl)(NC2=CC=C(F)C(C#CC3=CN=C(N)N=C3)=C2F)=O |
| Purity: | 99.03 |
| Description: | GCN2-IN-6 (Compound 6d) is a potent, and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50 of 1.8 nM) and cellular assays (IC50 of 9.3 nM). GCN2-IN-6 is also a eIF2? kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells)[1]. GCN2-IN-6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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