NDI-091143 [CAS 2375840-87-0]
Partner: MedChemexpress LLC
| CAS No: | 2375840-87-0 |
| Applications: | Neuroscience-Neuromodulation |
| MW: | 453.84 |
| Formula: | C20H14ClF2NO5S |
| SMILES: | O=C(OC)C1=CC(S(=O)(NC2=CC(C3=CC=CC=C3)=C(F)C=C2F)=O)=C(O)C(Cl)=C1 |
| Purity: | 99.94 |
| Description: | NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate[1]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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