Data Sheet

MSDS

ITI-214 [CAS 1642303-38-5]

CAS No:	1642303-38-5
Applications:	Neuroscience-Neuromodulation
MW:	605.56
Formula:	C₂₉H₂₉FN₇O₅P
SMILES:	O=C(C1=C(NC2=CC=CC=C2)N(CC3=CC=C(C4=NC(F)=CC=C4)C=C3)N=C1N56)N(C)C5=N[C@@]7([H])[C@]6([H])CCC7.O=P(O)(O)O
Purity:	99.58
Description:	ITI-214 is a potent, CNS-active, orally bioavailable PDE1 inhibitor (Ki of 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-214 inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively. ITI-214 shows efficacy in various animal models of motor and cognitive functions[1][2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only