Data Sheet

MSDS

Pifithrin-Alpha, p-Nitro, Cyclic [CAS 60477-38-5]

CAS No:	60477-38-5
Applications:	Neuroscience-Neurodegeneration
MW:	299.35
Formula:	C₁₅H₁₃N₃O₂S
SMILES:	O=[N+]([O-])C1=CC=C(C2=CN3C(SC4=C3CCCC4)=N2)C=C1
Purity:	99.73
Description:	Pifithrin-?, p-Nitro, Cyclic (PFN-?) is cell-permeable and active-form p53 inhibitor. Pifithrin-?, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-? in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-?, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-?, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue[1][2].
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only