Data Sheet

MSDS

LP-922761 (hydrate)

Applications:	Neuroscience-Neuromodulation
MW:	414.98
Formula:	C₂₁H₂₆N₆O₃.₁/₄H₂O
SMILES:	O=C(N(C)CCNC1=NN2C(C=C1)=NC=C2C3=CC=C(C=C3)C(N)=O)OC(C)(C)C.[H]O[H].[1/4]
Purity:	98.0
Description:	LP-922761 hydrate is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 hydrate also inhibits BMP-2-inducible protein kinase (BIKE) with an IC50 of 24 nM. LP-922761 hydrate shows less activity at cyclin G-associated kinase (GAK), opioid, adrenergic ?2 or GABAa receptors[1].
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only