E1231 [CAS 1031195-19-3]
Partner: MedChemexpress LLC
| CAS No: | 1031195-19-3 |
| Applications: | Neuroscience-Neuromodulation |
| MW: | 363.41 |
| Formula: | C21H21N3O3 |
| SMILES: | CC(N1CCN(C(C2=CC(C3=CC=C(C)O3)=NC4=CC=CC=C24)=O)CC1)=O |
| Purity: | 98.55 |
| Description: | E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 ?M), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (KD=9.61 ?M) and deacetylated liver X receptor-alpha (LXR?), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases[1]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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