RO2959 (monohydrochloride) [CAS 2309172-44-7]
Partner: MedChemexpress LLC
| CAS No: | 2309172-44-7 |
| Applications: | Neuroscience-Neuromodulation |
| MW: | 463.93 |
| Formula: | C21H20ClF2N5OS |
| SMILES: | O=C(NC1=NC=C(C2=C(C)CCN(C3=NC=C(C)S3)C2)N=C1)C4=C(F)C=CC=C4F.[H]Cl |
| Purity: | 98.21 |
| Description: | RO2959 monohydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 monohydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC50 of 25 nM. RO2959 monohydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways[1][2]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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