RO2959 (hydrochloride) [CAS 1219927-22-6]
Partner: MedChemexpress LLC
| CAS No: | 1219927-22-6 |
| Applications: | Neuroscience-Neuromodulation |
| MW: | N/A |
| Formula: | C21H19F2N5OS.xHCl |
| SMILES: | O=C(NC1=NC=C(C2=C(C)CCN(C3=NC=C(C)S3)C2)N=C1)C4=C(F)C=CC=C4F.[xHCl] |
| Purity: | 98.0 |
| Description: | RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC50 of 25 nM. RO2959 hydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways[1][2]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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