Data Sheet

MSDS

(1R)-IDH889 [CAS 1429179-08-7]

CAS No:	1429179-08-7
Applications:	Cancer-programmed cell death
MW:	436.48
Formula:	C₂₃H₂₅FN₆O₂
SMILES:	O=C1OC[C@H](C(C)C)N1C2=NC(N[C@@H](C3=NC=C(C4=CC=C(F)C(C)=C4)C=N3)C)=NC=C2
Purity:	98.83
Description:	(1R)-IDH889 is the inactive isomer of IDH889 (HY-112289), and can be used as an experimental control. IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 ?M, 0.072 ?M and 1.38 ?M for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 ?M[1].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only