Data Sheet

MSDS

PIM1-IN-1 [CAS 1417630-95-5]

CAS No:	1417630-95-5
Applications:	Cancer-Kinase/protease
MW:	474.56
Formula:	C₂₅H₃₀N₈O₂
SMILES:	COCCN1C2=C(C3=NN=C(C4=NC5=C(NCC6CCNCC6)C=CC=C5C=C4)N3N=C2)OCC1
Purity:	99.51
Description:	PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity[1].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only