Description: | ABT-384 is a potent, selective 11-?-hydroxysteroid dehydrogenase type 1 (11?-HSD1) inhibitor. ABT-384 exhibits high affinity (Ki 0.1-2.7 nM) against rodent, monkey, and human 11?-HSD1. ABT-384 blocks regeneration of active cortisol. ABT-384 can be used for the research of Alzheimer�s disease (AD)[1][2]. |