Data Sheet

MSDS

PHA-665752 [CAS 477575-56-7] (10mM in DMSO)

CAS No:	477575-56-7
Applications:	Cancer-Kinase/protease
MW:	641.61
Formula:	C₃₂H₃₄Cl₂N₄O₄S
SMILES:	O=C(C1=C(NC(/C=C2C(NC3=C\2C=C(C=C3)S(=O)(CC4=C(C=CC=C4Cl)Cl)=O)=O)=C1C)C)N5[C@H](CCC5)CN6CCCC6
Purity:	99.86
Description:	PHA-665752 is a selective, ATP-competitive, and active-site inhibitor of the catalytic activity of c-Met kinase (Ki=4 nM; IC50=9 nM). PHA-665752 exhibits >50-fold selectivity for c-Met compared with a panel of diverse tyrosine and serine-threonine kinases. PHA-665752 induces apoptosis and cell cycle arrest, and exhibits cytoreductive antitumor activity[1][2].
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only