Data Sheet

MSDS

(R,S,R)-ML334 [CAS 1432065-33-2]

CAS No:	1432065-33-2
MW:	446.50
Formula:	C₂₆H₂₆N₂O₅
SMILES:	O=C([C@H]1[C@@H](C(N2[C@@H](CN(C(C3=C4C=CC=C3)=O)C4=O)C5=C(C=CC=C5)CC2)=O)CCCC1)O
Purity:	98.40
Description:	(R,S,R)-ML334 is the inactive isomer of ML334 (HY-110258), and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 ?M. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity[1][2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only