Data Sheet

MSDS

JTE-607 [CAS 188791-09-5]

CAS No:	188791-09-5
Applications:	COVID-19-immunoregulation
MW:	597.36
Formula:	C₂₅H₃₃Cl₄N₃O₅
SMILES:	CCOC([C@H](CC1=CC=CC=C1)NC(C2=C(C(Cl)=C(C(Cl)=C2)OCCN3CCN(CC3)C)O)=O)=O.Cl.Cl
Purity:	99.27
Description:	JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-?, IL-1?, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC50s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively[1]. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607[2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only