Data Sheet

MSDS

(1S,2R)-Alicapistat [CAS 2221010-57-5]

CAS No:	2221010-57-5
Applications:	Neuroscience-Neurodegeneration
MW:	433.50
Formula:	C₂₅H₂₇N₃O₄
SMILES:	O=C1N([C@H](CC1)C(N[C@H](C(C(NC2CC2)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4
Purity:	98.0
Description:	(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD)[1]. (1S,2R)-Alicapistat mitigates the metabolic liability of carbonyl reduction and inhibits calpain 1 with an IC50 value of 395 nM[2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only