Data Sheet

MSDS

Nebentan [CAS 403604-85-3]

CAS No:	403604-85-3
Applications:	COVID-19-immunoregulation
MW:	491.52
Formula:	C₂₄H₂₁N₅O₅S
SMILES:	O=S(/C=C/C1=CC=CC=C1)(NC2=NC(C3=NC=CC=N3)=NC(OC)=C2OC4=CC=CC=C4OC)=O
Purity:	99.67
Description:	Nebentan (YM598 free base) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan (HY-A0013). Nebentan inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively[1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo[2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only