Data Sheet

MSDS

SB-657510 [CAS 474960-44-6]

CAS No:	474960-44-6
Applications:	Neuroscience-Neuromodulation
MW:	505.81
Formula:	C₁₉H₂₂BrClN₂O₅S
SMILES:	ClC(C=C1)=C(O[C@H]2CN(C)CC2)C=C1NS(C3=CC(OC)=C(OC)C=C3Br)(=O)=O
Purity:	99.84
Description:	SB-657510 is a selective urotensin II (UII) receptor (UT) antagonist. The Ki values are 61, 17, 30, 65 and 56 nM for human, monkey, cat, rat and mouse receptors, respectively. SB-657510 exerts anti-inflammatory effects by inhibiting UII-induced upregulation of inflammatory mediators such as adhesion molecules, cytokines, and tissue factor in human vascular endothelial cells[1][2].
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only