Data Sheet

MSDS

LY2811376 [CAS 1194044-20-6]

CAS No:	1194044-20-6
Applications:	Neuroscience-Neurodegeneration
MW:	320.36
Formula:	C₁₅H₁₄F₂N₄S
SMILES:	FC1=C(C2=CN=CN=C2)C=C([C@]3(C)CCSC(N3)=N)C(F)=C1
Purity:	99.89
Description:	LY2811376 is the first orally available non-peptidic ?-secretase (BACE1) inhibitor with IC50 of 239 nM-249 nM, that acts to decrease A? secretion with EC50 of 300 nM, and demonstrates to have 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition over other aspartic proteases including cathepsin D, pepsin, or renin.
Shipping Conditions:	Ship at ambient
Usage:	Research Use Only