NAZ2329 [CAS 2809469-05-2]
Partner: MedChemexpress LLC
| CAS No: | 2809469-05-2 |
| Applications: | Cancer-Kinase/protease |
| MW: | 501.56 |
| Formula: | C21H18F3NO4S3 |
| SMILES: | CCOC1=C(CSC2=C(C(NS(=O)(C3=CC=CC=C3)=O)=O)SC=C2)C=C(C(F)(F)F)C=C1 |
| Purity: | 99.57 |
| Description: | NAZ2329, the first cell-permeable inhibitor of R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs), allosterically and preferentially inhibits PTPRZ (IC50=7.5 µM for hPTPRZ1) and PTPRG (IC50=4.8 µM for hPTPRG) over other PTPs. NAZ2329 binds to the active D1 domain and more potently inhibits PTPRZ-D1 fragment (IC50 of 1.1 µM) than the whole intracellular (D1 + D2) fragment (IC50 of 7.5 µM). NAZ2329 can effectively inhibit tumor growth of the glioblastoma cells and suppress stem cell-like properties[1]. |
| Shipping Conditions: | Ship at ambient |
| Usage: | Research Use Only |
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