Data Sheet

MSDS

Midostaurin [CAS 120685-11-2] (10mM in DMSO)

CAS No:	120685-11-2
Applications:	Cancer-Kinase/protease
MW:	570.64
Formula:	C₃₅H₃₀N₄O₄
SMILES:	O=C(C1=CC=CC=C1)N(C)[C@H]2[C@@H](OC)[C@@]3(C)N(C4=C5C=CC=C4)C6=C5C7=C(C(NC7)=O)C8=C6N(C9=CC=CC=C98)[C@@](O3)([H])C2
Purity:	99.95
Description:	Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKC?/?/?, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFR? and VEGFR1/2 with IC50s ranging from 22-500 nM[1][2]. Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects[3].
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only