Data Sheet

MSDS

Vorinostat [CAS 149647-78-9] (10mM in DMSO)

CAS No:	149647-78-9
Applications:	Cancer-programmed cell death
MW:	264.32
Formula:	C₁₄H₂₀N₂O₃
SMILES:	O=C(NC1=CC=CC=C1)CCCCCCC(NO)=O
Purity:	99.62
Description:	Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC6 and HDAC7 (Class II) and HDAC11 (Class IV), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis[1][4]. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification[7].
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only