Data Sheet

MSDS

RG-12525 [CAS 120128-20-3] (10mM in DMSO)

CAS No:	120128-20-3
Applications:	Metabolism-sugar/lipid metabolism
MW:	423.47
Formula:	C₂₅H₂₁N₅O₂
SMILES:	C1(COC2=CC=C(OCC3=CC=CC=C3CC4=NN=NN4)C=C2)=NC5=CC=CC=C5C=C1
Purity:	98.39
Description:	RG-12525 is a a specific, competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4, inhibiting LTC4-, LTD4- and LTE4-inducd guinea pig parenchymal strips contractions, with IC50s of 2.6 nM, 2.5 nM and 7 nM, respectively; RG-12525 is also a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist with IC50 of appr 60 nM and a potent inhibitor of CYP3A4, with a Ki value of 0.5 �M.
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only