Data Sheet

MSDS

(S)-Crizotinib [CAS 1374356-45-2] (10mM in DMSO)

CAS No:	1374356-45-2
Applications:	Neuroscience-Neurodegeneration
MW:	450.34
Formula:	C₂₁H₂₂Cl₂FN₅O
SMILES:	NC1=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@H](C4=C(Cl)C=CC(F)=C4Cl)C
Purity:	99.61
Description:	(S)-Crizotinib is a potent and selective MTH1 (mutT homologue) inhibitor with an IC50 of 330 nM. (S)-Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumour growth in animal models[1].
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only