Data Sheet

MSDS

PD-161570 [CAS 192705-80-9] (10mM in DMSO)

CAS No:	192705-80-9
Applications:	Cancer-Kinase/protease
MW:	532.51
Formula:	C₂₆H₃₅Cl₂N₇O
SMILES:	O=C(NC(C)(C)C)NC1=NC2=NC(NCCCCN(CC)CC)=NC=C2C=C1C3=C(Cl)C=CC=C3Cl
Purity:	99.04
Description:	PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively[1][2]. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-? signaling inhibitor[3].
Shipping Conditions:	Ship on cold packs
Usage:	Research Use Only